Let’s talk about a supplement that’s not flashy, trendy, or even particularly well-known — but it quietly does a whole lot of good: N-Acetylglucosamine (or NAG).

If you’ve ever battled leaky gut, autoimmune flares, or mystery inflammation, you might already know the name. But if you don’t — let me introduce you to one of the calmest, most supportive additions to my healing toolkit.

What is NAG?

NAG is a form of glucosamine, a naturally occurring amino sugar found in your body. But unlike the type found in joint supplements (glucosamine sulfate), NAG focuses on the gut lining — and that’s where it really shines.

It supports the mucosal layer of the intestines — think of this as the inner “skin” that protects your gut from irritants, bacteria, and immune overreactions. When that layer is damaged (hello, gluten exposures, stress, medications, and infections), your gut lining becomes leaky and inflamed.

Why I Take It:

I have Celiac disease and a history of gut issues, so protecting and healing my gut lining is non-negotiable. I can’t take L-glutamine (which is often recommended for gut repair), so NAG is my go-to.

Here’s what I’ve noticed since adding it:

Less post-meal urgency Calmer digestion overall My system just feels… less reactive

It doesn’t stimulate my system — it soothes it.

The Science (Short + Sweet):

NAG helps rebuild the intestinal lining It has anti-inflammatory effects in the GI tract It may reduce symptoms of inflammatory bowel disease (IBD), according to small clinical trials Some evidence shows it may also protect the bladder and joints

Bonus: It’s generally well tolerated, even for sensitive people like me.

I’m not a Doctor, but…

If you’re on a gut healing journey and looking for a gentle, non-aggressive helper — consider NAG. Especially if you can’t take glutamine, this is a beautiful, quiet substitute that supports you without overwhelming your system.

I take mine first thing in the morning, away from food, with enzymes or trace minerals — depending on the day. And I can honestly say it’s one of the few supplements I take where I feel the difference.

** Always consult with the doctor before trying a new supplement. I am not a doctor. These are based on my own personal experiences and research under doctors advice.